Located in Florence, South Carolina, Timmonsville Regional Airport is a public use airport located 2 nautical miles (4 km) northeast of the central business district of Timmonsville. According to the FAA's Airport/Facility Directory, the airport had 1,418 aircraft operations in calendar year 2010, an increase from 1,362 in 2009. The majority of operations are general aviation with no commercial service.

Timmonsville Regional Airport covers an area of 395 acres (156 ha) at an elevation of 513 feet (157 m) above mean sea level. It has one runway designated 8/26 with an asphalt surface measuring 6,000 by 100 feet (1,829 x 30 m). For the 12-month period ending December 31, 2010, the airport had 52,000 aircraft operations, an average of 143 per day: 97% general aviation and 3% air taxi.